Prognostic Value of C-reactive Protein Combined with Systemic Immune Inflammatory Index in Non-senile Aneurysmal Subarachnoid Hemorrhage
Objective To investigate prognostic value of C-reactive protein(CRP)and systemic immune inflammation index(S Ⅱ)for neurological outcome in non-older patients with aneurysmal subarachnoid hemorrhage(aSAH).Methods The clinical data of 108 aSAH patients hospitalized the Fifth Affiliated Hospital of Zhengzhou University were collected from July 2021 to April 2023.According to the modified Rankin scale(mRS)score at 3 months,the datas were divided into favorable(mRS,0 to 2 score)and unfavorable outcome(mRS,3 to 6 score).The characteristics were compared between aSAH patients with favorable and unfavorable outcome.In addition,receiver operating characteristic(ROC)curves were undertaken to evaluate the predictive value of different independent influencing factors in patients with aSAH.Results A total of 108 patients with aSAH were enrolled,including 48 patients with favorable and 60 patients with unfavorable outcome.Univariate analysis showed statistically differences between the two groups in terms of Fisher grade,Hunt-Hess grade,white blood cell count,neutrophil count,lymphocyte count,CRP,and S Ⅱ(P＜0.05).In multivariate logistic regression analysis,it exhibited that Fisher grade,CRP,SⅡ were independent predictors in non-old aSAH patients.ROC curve analysis showed that the area under the curve(AUC),sensitivity and specificity of CRP and S Ⅱ in predicting poor prognosis of non-elderly aSAH patients were 0.874,99.9％,60.0％and 0.881,95.8％,63.3％,respectively.The AUC,sensitivity and specificity of the combined prediction of poor prognosis in non-elderly aSAH patients were 0.911,72.9％and 95.0％,respectively.Conclusion Early elevated CRP and S Ⅱ are the significant indicators of unfavorable outcome in non-old aSAH patients,and the combination has the highest predictive value.
万方数据
维普
