Pathogenic Bacteria of Multidrug-Resistant Organisms Infection and Related Factors in Coma-Promoted Awakening Patients in Neurosurgical
Objective To investigate the pathogenic bacteria of multidrug-resistant organisms(MDRO)infections in patients of the neurosurgical coma-promotion center,and construct a logistic regression model to further analyze the influencing factors,aiming to provide a scientific basis for clinical formulation of preventive and intervention measures.Methods From May 2021 to December 2022,211 patients admitted to the neurosurgical coma promotion center in hospital were used as study subjects.Sputum specimens were collected for pathogenic bacteria culture and drug sensitivity test,and the pathogenic bacteria detection and drug resistance rate were counted.According to whether MDRO,the patients were divided into observation group(yes)and control group(no).Logistic regression equations were used to analyze the factors that influenced the occurrence of MDRO in patients with coma and awakening,and logistic regression equation was used to analyze the influencing factors of MDRO in coma-induced awakening patients.Results A total of 285 strains of pathogenic bacteria were detected in 211 sputum samples,among which 130 cases were MDRO(188 strains).The proportions of extended spectrum beta-lactamases(ESBLs)-producing Enterobacteriaceae bacteria,carbapenem-resistant Acinetobacter baumannii(CR-AB),and Methicillin-resistant staphylococcus aureus(MRSA)were 54.26％,32.98％,and 12.77％,respectively.There were statistically differences in age,mechanical ventilation duration,blood glucose level,combined use of antibiotics,National Institute of health stroke scale(NIHSS)score and nutritional risk between the two groups(P＜0.05).Age,mechanical ventilation duration,blood glucose level,combined use of antibiotics,NIHSS score(OR=17.346),nutritional risk were risk factors for MDRO(P＜0.05).Conclusion Age,mechanical ventilation time,blood glucose level,combined use of antibiotics,NIHSS score and nutritional risk are the risk factors for inducing MDRO.It is recommended to take clinical measures to prevent nosocomial infection.
万方数据
维普
