Effect of Minimally Invasive Incision on the Postoperative Recovery and Serum Inflammatory Cytokine Levels in Patients Undergoing Radical Esophagectomy for Esophageal Cancer Through the Left Posterior Lateral Thoracic Incision
Objective To explore the efficacy of radical resection of esophageal cancer(EC)through left posterolateral minimally invasive incision and its effect on postoperative rehabilitation and serum inflammatory factors.Methods A total of 82 EC patients admitted to the hospital from January 2021 to February 2023 were randomly divided into group A(41 cases)and group B(41 cases).Group B received dual incision(right chest upper abdomen)EC radical surgery,while group A received EC radical surgery through a minimally invasive incision on the posterior lateral side of the left chest.The surgical indexes,lung function[forced vital capacity(FVC),vital capacity(VC),maximal voluntary ventilation(MVV)],pain mediators[substance P(SP),prostaglandin E2(PGE-2),neuropeptide Y(NPY)],inflammatory factors[tumor necrosis factor-α(TNF-α),procalcitonin(PCT)],interleukin-6(IL-6),C-reactive protein(CRP)]levels,complication rate were compared between the two groups.Results There was no statistically difference in the number of lymph node dissection between the two groups(P＞0.05).The intraoperative blood loss in group A was lower than that in group B,and the surgical and hospitalization time was shorter than that in group B(P＜0.05).Three months after surgery,the levels of FVC,VC,and MVV in both groups decreased,and the levels in group A was lower than in group B(P＜0.05).Three days after surgery,the levels of two groups of serum SP,NPY,PGE-2,TNF-α,PCT,IL-6,and CRP increased,and the levels in group B were higher than those in group A(P＜0.05).The incidence of complications in group A was lower than that in group B(P＜0.05).Conclusion Two-incision EC radical resection(right thoracic-upper abdomen)has the same efficacy as minimally invasive EC radical resection via left posterolateral thoracic incision for lymph node dissection in EC patients,but the former has less impact on lung function,while the latter is more helpful to optimize surgical indicators,reduce complications,relieve pain,and have less impact on inflammatory stress response.
万方数据
维普
