Correlation of Serum HMGB1,CCL20,HSP27 Levels with the Degree of Periodontal Disease in Patients with Chronic Periodontitis
Objective To investigate the correlation between the levels of serum high mobility group protein 1(HMGB1),CC chemokine ligand 20(CCL20)and heat shock protein 27(HSP27)and the degree of periodontal disease in patients with chronic periodontitis(CP).Methods A total of 60 patients with CP diagnosed and treated in the First Affiliated Hospital of Xinxiang Medical College from September 2021 to August 2023 were included in the observation group,and another 60 patients with healthy periodontal conditions were included in the control group according to the 1∶1 case selection principle.The serum levels of HMGB1,CCL20 and HSP27 were compared between the two groups and CP patients with different degrees of periodontal disease,and the correlation between each index level and the degree of CP periodontal disease and the combined diagnostic value were analyzed,and the risk of CP in patients with different serum levels was analyzed.Results The serum levels of HMGB1,CCL20 and HSP27 in observation group were higher than those in control group(P＜0.05).The serum levels of HMGB1,CCL20 and HSP27 in CP patients with different degrees of periodontal disease were compared as follows:mild＜moderate＜severe,and each index level was positively correlated with the degree of periodontal disease(P＜0.05).At admission,the area under the curve(AUC)of the combined diagnosis of CP with HMGB1,CCL20 and HSP27 levels was 0.905,the best diagnostic sensitivity was 91.67％,the specificity was 88.33％,and the Jordon index was 0.800.The risk of CP in patients with high levels of each index was 1.105 times,1.034 times,1.105 times higher than that in patients with low levels(P＜0.05).Conclusion HMGB1,CCL20 and HSP27 are abnormally high expressed in the serum of CP patients,and the levels of each index are positively correlated with the degree of periodontal disease,and the combined detection has high diagnostic value for CP,which can be used as an effective index for clinical diagnosis of CP and evaluation of the degree of periodontal disease.
high mobility group protein 1CC chemokine ligand 20heat shock protein 27chronic periodontitis
万方数据
维普
