Correlation Between Cognitive Impairment and White Matter Lesions in Patients with Cerebral Infarction
Objective To explore the correlation between cognitive impairment and white matter lesions(WML)in patients with cerebral infarction(CI),and to analyze the risk factors of cognitive impairment complicated with WML based on multivariate logistic regression.Methods A total of 134 patients with CI admitted to our hospital from August 2020 to October 2022 were selected as research objects.According to whether cognitive impairment occurred,they were divided into the developing group(56 cases)and the non-developing group(78 cases).Baseline data of the two groups were compared to analyze the correlation between cognitive impairment and age-related white matter change score(ARWMC).According to the occurrence of WML lesions,patients in the occurrence group were divided into 36 patients with non-lesions and 20 patients with lesions.Serological indexes[retinol-binding protein(RBP),Galectin-3,interleukin-33(IL-33)]in patients with lesions and non-lesions were analyzed.Multivariate logistic regression analysis of the risk factors of cognitive impairment complicated with WML.To evaluate the predictive value of risk factors in predicting cognitive impairment complicated with WML.Results There was a linear relationship between cognitive impairment and ARWMC score on admission(P=0.005),and a positive correlation between cognitive impairment and ARWMC score on admission(r=0.485,P＜0.001).The age,NIHSS score at admission,the proportion of severe carotid artery stenosis and the proportion of multiple infarcts were higher in patients with pathological changes than those without pathological changes,and the serum levels of RBP,Galectin-3 and IL-33 were higher than those without pathological changes(P＜0.05).Advanced age,increased NIHSS score at admission,aggravated carotid artery stenosis,multiple infarcts and increased serum RBP,Galectin-3,IL-33 levels were all risk factors for cognitive impairment complicated with WML(P＜0.05).The area under curve of cognitive impairment combined with WML was higher than that of serum RBP,Galectin-3,IL-33 alone(P＜0.05).Conclusion Cognitive impairment in CI patients is positively correlated with WML.Aging,increased NIHSS score upon admission,increased degree of carotid artery stenosis,multiple infarcts and increased serum RBP,Galectin-3 and IL-33 levels are risk factors for cognitive impairment complicated with WML.Logistic regression prediction model was established based on risk factors.The model has a certain predictive value for cognitive impairment complicated with WML.
万方数据
维普
