Investigation of Severe Hepatitis Co-infection and Analysis of Related Influencing Factors
Objective To investigate the incidence and related influencing factors of severe hepatitis co-infection.Methods A total of 219 patients with severe hepatitis admitted to Nanyang central Hospital from April 2021 to January 2023 were divided into infected group(84 cases)and uninfected group(135 cases)according to whether they were co-infected.To analyze the incidence of infection in patients with severe hepatitis.Gender,age,body mass index(BMI),course of disease,invasive procedure,use of antibiotics,leukocytes,neutrophils,albumin,gastrointestinal bleeding,hypokalemia,cholinesterase,cholesterol,creatinine,blood glucose,serum soluble leukocyte differentiation antigen CD14 subtype(Presepsin),and serum soluble tumor necrosis factor Apoptosis-inducing ligand(sTRAIL),serum interleukin-15(IL-15),serum pentamerin 3(PTX3),serum heparin binding protein(HBP)were compared between the two groups.Logistic multivariate analysis of the risk factors associated with severe hepatitis co-infection and the predictive value of serum indexes for severe hepatitis co-infection.Results Among 219 patients with severe hepatitis,84 were co-infected,the infection rate was 38.36％.There were significant differences in the levels of antibiotics,serum Presepsin,sTRAIL,IL-15,PTX3 and HBP between the two groups(P＜0.05).Serum Presepsin,sTRAIL,IL-15,PTX3 and HBP levels were risk factors for severe hepatitis co-infection(P＜0.05),and rational use of antibiotics was protective factor for severe hepatitis co-infection(P＜0.05).The area under curve of serum presepsin,sTRAIL,IL-15,PTX3 and HBP combined to predict severe hepatitis co-infection was higher than that of each single index(P＜0.05).Conclusion Patients with severe hepatitis have a higher risk of infection,which is mainly related to the use of antibiotics and the levels of serum Presepsin,sTRAIL,IL-15,PTX3,HBP and other factors.Serum Presepsin,sTRAIL,IL-15,PTX3,HBP can be used as an early screening program for monitoring.
万方数据
维普
