Objective To compare the effects of different anticoagulation regimens on emergency sepsis patients treated with continuous renal replacement therapy(CRRT),and analyze the impact on their inflammatory status and bleeding risk.Methods Retrospective analysis of data from 110 emergency sepsis patients admitted to the hospital from January 2020 to December 2022 who received CRRT treatment.58 patients who received low-molecular-weight heparin anticoagulation were included in the control group,and 52 patients who received local citrate anticoagulation were included in the observation group.The levels of inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]and coagulation function indexes[prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(Fib)]were compared between the two groups before and after treatment,and the atrial fibrillation anticoagulant therapy bleeding scoring system was used to evaluate the bleeding risk after treatment.Results After treatment,serum TNF levels in both groups of patients-α、The average level of IL-6 water decreased,and the level in the observation group was lower than that in the control group(P＜0.05).The PT and APTT levels decreased and Fib levels increased in both groups of patients,and the observation group had lower PT and APTT levels than the control group,while Fib levels were higher than the control group(P＜0.05).The observation group had lower bleeding scores in the anticoagulant therapy for atrial fibrillation compared to the control group(P＜0.05).Conclusion Compared with low molecular weight heparin anticoagulation,the use of local citrate anticoagulation can better alleviate the inflammatory response,improve coagulation function,and reduce the risk of bleeding in emergency sepsis patients undergoing CRRT treatment.
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