Effect of Sequential Hormone Therapy Combined with Immunoglobulin on Kawasaki Disease in Children
Objective To observe the effect of sequential hormone therapy combined with immunoglobulin on Kawasaki disease in children.Methods A total of 100 children with Kawasaki disease who did not respond to immunoglobulin treatment from January to December 2022 were prospectively selected and divided into control group and observation group according to random number table method,with 50 cases in each group.The control group received immunoglobulin pulse therapy,and the observation group received hormone sequential therapy on the basis of the control group.Observe the time when the children's symptoms subsided.The levels of inflammatory indicators[C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),white blood cell(WBC)]and cytokines[matrix metalloproteinase-9(MMP-9),vascular endothelial growth factor(VEGF)]were compared between the two groups before and after treatment for 2 weeks,and the occurrence of adverse reactions during treatment was counted.Follow-up for 12 weeks to record the cardiovascular damage.Results The regression time of main symptoms in the observation group was shorter than that in the control group(P＜0.05).After treatment,CRP,ESR,WBC,MMP-9 and VEGF in the two groups were lower than before treatment,and the observation group was lower than the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups during treatment(P＞0.05).Follow-up for 12 weeks showed that the total incidence of cardiovascular damage in the observation group was lower than that in the control group(P＜0.05).Conclusion Hormone sequential therapy combined with immunoglobulin can promote the improvement of symptoms,reduce inflammatory reaction,reduce the expression of MMP-9 and VEGF,and reduce the risk of cardiovascular damage in children with Kawasaki disease without immunoglobulin response.
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