Sedative Effect of Remazolam Besylate in Severe Patients After Cardiac Surgery
Objective To investigate the sedative effect of remazolam benzoate on cognitive function and hemodynamics in patients with severe cardiac surgery.Methods A prospective randomized controlled study was conducted to select 80 postoperative cardiac surgery patients admitted to the intensive care unit in hospitals from January to December 2022.According to the order of visits,the patients were divided into groups using a single and double number method,with 40 patients in each group.Group A received remimazolam besylate sedative,group B received metomidine sedatives.Sedation effect,postoperative recovery,hemodynamics[mixed/central venous oxygen saturation(SvO2/ScvO2),mean arterial pressure(MAP),heart rate(HR)],cognitive function and adverse reactions were compared between the two groups.Results The target sedation time,satisfaction time with sedation depth,and recovery time after discontinuation of medication in group A were shorter than those in group B(P＜0.05).The first offline time in group A was shorter than that in group B(P＜0.05),and the mechanical ventilation time and ICU stay time were shorter than those in group B,but there was no statistically significant difference between the groups(P＞0.05).At T1-2,HR and MAP in group A were higher than those in group B,while SvO2/ScvO2 was lower than that in group B,but there was no statistically difference between the groups(P＞0.05).At 2 and 24 hours after discontinuation,the MMSE scores of both groups were higher than before sedation,but there was no statistically difference between the groups(P＞0.05).The incidence of cognitive impairment in group A was lower than that in group B(P＜0.05).During the perioperative period,there was no statistically difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Compared with dexmedetomidine,remazolam besylate can reduce cognitive impairment,promote postoperative recovery and provide satisfactory sedative effect in patients with severe cardiac surgery.
remazolam benzoatedexmedetomidinesedationcardiac surgery
万方数据
维普
