Mechanism of Shengxian Decoction in the Treatment of Chronic Heart Failure Based on Network Pharmacology
Objective To explore the mechanism of Shengxian decoction in the treatment of chronic heart failure based on network pharmacology methods.Methods TCMSP,Pubchem and Swiss Target Prediction were used to screen the active ingredients and targets of Shengxian decoction.GeneCard,OMIM and Drugbank databases were used to obtain and screen the targets associated with chronic heart failure.Protein interaction was analyzed using STRING platform,network was constructed,and gene ontology and Kyoto Encyclopedia of Genes and Genomes biological pathway enrichment analysis were performed on target genes using David database.Results A total of 56 active ingredients were screened and 141 potential targets were identified.The core active ingredients were kaempferol,quercetin,stigmasterol,isorhamnetin,luteolin,and astragalosides,with PTGS2,STAT3,TP53,EGFR and MMP9 as core targets.Key pathways included AGE-RAGE signaling pathway,PI3K-Akt signaling pathway,IL-17 signaling pathway,HIF-1 signaling pathway and TNF signaling pathway.Conclusion The main substance basis for the treatment of chronic heart failure with Shengxian decoction may be flavonoids,sterols and saponins.Its potential mechanism of action that to inhibit myocardial cell apoptosis,improve ventricular remodeling,inhibit inflammatory response,and oxidative stress.In the future,molecular research should be conducted for further validation.
万方数据
维普
