目的 分析溃疡性结肠炎(UC)生物制剂的研究现状、热点和发展趋势,为我国UC生物制剂的相关研究提供参考.方法 检索Web of Science核心合集数据库中发表于2013年1月1日至2022年12月31日关于UC生物制剂研究的相关文献,利用文献计量在线分析平台(https://bibliometric.com/)和CiteSpace软件统计分析相关研究的发文量、国家/地区、机构、作者、期刊等文献关键特征.结果 共纳人文献3 928篇,年发文量整体呈逐年增加的趋势;开展该领域研究的国家/地区有109个,美国占领先优势(1 209篇,占总发文量的31.03％),且与其他国家合作密切;参与该领域研究的机构共456个,加州大学圣地亚哥分校的发文量(121篇)和中心度(0.09)均排名首位;发文量最大的作者是法国洛林大学的Peyrin-Biroulet L(101篇),共被引频次排名首位的作者是加州大学圣地亚哥分校的Sandborn W J(1 055次);共计1 012个期刊发表了相关文献,发文量和共被引频次最高的期刊均为Inflammatory Bowel Diseases(267篇,1 376次);共被引频次最高的文献是Ungaro等在2017年发表的综述"Ulcerative colitis",共被引文献中心度排名首位的是Sandborn等在 2017 年发表的"Tofacitinib as induction and maintenance therapy for ulcerative colitis";该领域的研究热点主要集中在生物制剂有效性、治疗药物监测、特殊群体用药、药物经济学评价等方面.结论 我国UC生物制剂的研究与国外相比还存在一定差距,应加强国际合作交流,及时跟进该领域的研究热点和未来发展趋势.
Research Status and Hotspot Analysis of Biologics for Ulcerative Colitis
Objective To analyze the research status,hotspots and development trend of biologics for the treatment of ulcerative colitis(UC),and to provide reference for the related research of UC biologics.Methods The relevant literatures on UC biologics published in the Web of Science core database from January 1,2013 to December 31,2022 were searched.Number of publications,country/region,organization,authors,journals and other literature key characteristics of the related studies were identificated by using literature metrological analysis online platform(https://bibliometric.com/)and statistical analysis software CiteSpace.Results A total of 3 928 literatures were included,with the number of publications increasing year by year.There were 109 countries/regions that carried out research in this field,with the US taking the lead(1 209 articles,31.03％of the total number of papers),and close cooperation with other countries.A total of 456 institutions participated in the research,and the University of California,San Diego ranked first in the number of publications(121 articles)and the degree of centrality(0.09).The author of the most published paper was Peyrin-Biroulet L(101 articles)from the University of Lorraine in France.The most frequently cited author was Sandborn W J(1 055 times)of the University of California,San Diego.A total of 1 012 journals published relevant literatures,and the journals with the highest number of publications and total citation frequency were Inflammatory Bowel Diseases(267 articles,1 376 times).The literature with the highest co-citation frequency was the review"Ulcerative colitis"published by professor Ungaro R et al,in 2017.The literature"Tofacitinib as induction and maintenance therapy for ulcerative colitis"ranked first in the center degree of co-citation literature published by Sandborn W J et al in 2017.The research in this field mainly focuses on the effectiveness of biological agents,therapeutic drug monitoring,drug use in special groups,pharmacoeconomic evaluation,etc.Conclusion There is still a gap between the research of UC biologies in China and abroad.International cooperation and communication should be strengthened,and the research hotspots and future development trends in this field should be followed up in time.
万方数据
维普
