首页|初筛谷丙转氨酶结果偏高献血者的补救方法

初筛谷丙转氨酶结果偏高献血者的补救方法

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目的 通过初筛无偿献血者谷丙转氨酶(ALT),对献血前ALT初筛结果偏高的献血者制定相应补救措施,一定程度上解决生理因素引起的献血前ALT异常造成的献血者流失问题.方法 采用干式生化法,对2022年1-6月至河南省某血站的所有无偿献血者进行ALT初筛,对于ALT>45 U·L-1且乙肝和血红蛋白初筛合格的献血者重复初筛检测3次,取3次结果的平均值,如仍>45 U·L-1则进行相应干预措施,献血后采用速率法复检ALT,比较干预前后献血合格率及血液ALT报废率情况.结果 对乙肝和血红蛋白初筛合格的献血员,ALT水平在45~50 U·L-1者,嘱其安静休息30 min复测ALT.结果显示,在安静休息30 min后,ALT轻度偏高的献血者,初筛ALT检测值越低,复测ALT合格率越高,实施补救措施的献血员献血后追踪复检ALT合格率为99.9%.对于安静休息30 min后复测ALT仍不合格者,嘱其清淡饮食、避免饮酒和熬夜,5~7 d后1 250名该类人员参与献血健康检查,其中430名初筛ALT合格,献血后追踪复检ALT合格率为99.7%.结论 对于初筛ALT不合格献血员,通过实施相应干预措施,可使部分ALT异常的献血者降至正常,提升献血合格率,在一定程度上缓解临床用血紧张.
Remedial Methods for Blood Donors with High Alanine Transaminase Results in Initial Screening
Objective Through to screen the alanine transaminase(ALT)of voluntary blood donors,and formulate corresponding remedial measures for blood donors with high ALT screening results before blood donation,so as to solve the problem of blood donor loss caused by abnormal ALT before blood donation caused by physiological factors to a certain extent.Methods All voluntary blood donors from January to June,2022 were screened for ALT by dry biochemical method.The donors with ALT>45 U·L-1 and qualified hepatitis B and hemoglobin preliminary screening were repeated for 3 times,and the average value of the 3 results was taken.If the ALT was still>45 U·L-1,appropriate intervention measures were taken.The qualified rate of blood donation and ALT abandonment rate were compared before and after the intervention.Results The blood donors who passed the primary screening of hepatitis B and hemoglobin were told to rest quietly for 30 minutes if the ALT level was between 45-50 U·L-1.The results showed that after 30 minutes of quiet rest,the lower the ALT detection value in the preliminary screening,the higher the qualified rate of the retest ALT.The qualified rate of the retest ALT was 99.9%in the blood donors who implemented remedial measures.For those who still failed to retest ALT after resting quietly for 30 minutes,they were instructed to eat lightly,avoid drinking alcohol and stay up late.After 5-7 days,1 250 such people participated in the health examination of blood donation,among which 430 people passed the primary screening of ALT,and the passing rate of ALT reexamination after blood donation was 99.7%.Conclusion For the blood donors with unqualified ALT in the initial screening,some blood donors with abnormal ALT can be reduced to normal by implementing the corresponding intervention measures,improving the qualified rate of blood donation and relieving the tension of clinical blood use to a certain extent.

alanine transaminaseprimary screeningvoluntary blood donor

祝丽双、王浩

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河南中医药大学第五临床医学院/郑州人民医院输血科,河南郑州 450000

河南省人民医院眼科,河南郑州 450000

谷丙转氨酶 初筛 无偿献血者

河南省医学科技攻关计划联合共建项目河南中医药大学科研苗圃工程项目

LHGJ20210699MP2021-4

2024

河南医学研究
河南省医学科学院

河南医学研究

影响因子:0.979
ISSN:1004-437X
年,卷(期):2024.33(3)
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