Effects of Remiazolam Sedation on Short-Term Stress Indexes and Prognosis in Patients with Delayed Cerebral Ischemia After Interventional Therapy for Intracranial Aneurysm Rupture
Objective To investigate the effect of remiazolam sedation on short-term stress indexes and prognosis of patients with delayed ischemic disorder after interventional therapy for ruptured Intracranial aneurysm.Methods From April 2021 to April 2023,98 patients with subarachnoid hemorrhage who were treated in Kaifeng People's Hospital after intervention were selected and randomly divided into three groups:A group(ramazolam 0.05 mg·kg-1·h-1)32 patients,AA group(ramazolam 0.15 mg·kg-1·h-1)32 patients and control group(no ramazolam)34 patients.All patients were treated for 14 consecutive days.The prognosis was assessed using the National Institutes of Health Stroke Scale score,with a score≥15 indicating poor prognosis and a score＜15 indicating good prognosis.The changes of stress index β-endorphin(β-EP),S100β protein and neuron specific enolase(NSE)levels in 3 groups before and after treatment and the incidence and prognostic effects of delayed cerebral ischemia cerebral vasospasm in 3 groups were compared.Results There was no significant difference in β-EP,S100β and NSE levels among 3 groups before treatment(P＞0.05).The levels of serum β-EP,S100β and NSE in group AA after treatment were better than those in A group and control group,and the difference was statistically significant(P＜0.05).There was no statistically significant difference in the occurrence time of delayed ischemic cerebral vasospasm among the three groups before treatment(P＞0.05).The duration and incidence of cerebral vasospasm in the AA group were better than those in the A group and the control group,and the difference was statistically significant(P＜0.05).Among the patients with good prognosis,A A group was 84.3％,and the overall prognosis was better than A group(58.8％)and control group(56.2％),the difference was statistically significant(P＜0.05).The total incidence of adverse reactions among the three groups of patients was 11.4％in A group,15.6％in AA group,and 8.8％in the control group,with no statistically significant difference(P＞0.05).Conclusion Sedative treatment of ramazolam may improve brain tissue metabolism and cerebral vasospasm.Compared with low concentration of ramazolam,high concentration of ramazolam has better brain tissue protection and reduces the occurrence of cerebral vasospasm,which has a certain effect on improving the clinical prognosis of patients with ruptured Intracranial aneurysm.
remazolamintracranial aneurysmcerebral vasospasmbrain function injuryprognosis
万方数据
维普
