Effects of Low-Frequency Repetitive Transcranial Magnetic Stimulation on Cognitive Function and Serum Neurotrophic Factors in Adolescents with Depression
Objective To investigate the clinical effect and nursing strategy of low-frequency repetitive transcranial magnetic stimulation(rTMS)adjuvant therapy in adolescents with depression.Methods A total of 86 adolescents with depression were selected from a tertiary A hospital in Henan Province from July 2020 to June 2022,and were randomly divided into observation group(43 cases)and control group(43 cases)by random number table method.The two groups were given oral antidepressants,and the observation group was combined with low-frequency rTMS.The treatment lasted 8 weeks.Depressive symptom was assessed by Hamilton depression scale-24(HAMD-24),cognitive function was assessed by repeatable battery for the assessment of neuropsye hological status(RBANS)and Montreal cognitive assessment scale(MoCA),and serum neurotrophic factors were assessed by enzyme-linked immunosorbent assay.Adverse reactions were recorded during treatment.Results At 3 and 6 weeks of treatment,the scores of HAMD-24 were decreased in both groups,and the scores of HAMD-24 in the observation group were lower than those in the control group at two time points(P＜0.05).At 6 weeks of treatment,the scores of RBANS and MoCA were increased in both groups,and serum levels of brain-derived neurotrophic factor and nerve growth factor were increased in both groups(P＜0.05).The scores of cognitive function scale and serum levels of neurotrophic factor in the observation group were higher than the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups during treatment(P＞0.05).Conclusion The treatment of antidepressant drugs combined with low-frequency rTMS could effectively reduce the severity of adolescents with depression,improve cognitive function and serum neurotrophic factor,with good clinical safety.
depressionadolescentrepetitive transcranial magnetic stimulationcognitive functionneurotrophic factornursing countermeasure
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维普
