Effect of Nasal High Flow Humidification Oxygen Therapy and Non-invasive Positive Pressure Ventilation in the Treatment of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated with Type Ⅱ Respiratory Failure
Objective To explore the effect of high-flow nasal cannula oxygen therapy(HFNC)and non-invasive positive pressure ventilation(NIPPV)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)of type Ⅱrespiratory failure(Ⅱ-RF).Methods Eighty patients with AECOPD complicated with Ⅱ-RF from January to December 2022 were selected and divided into HFNC group and NIPPV group according to different ventilation methods,with 40 cases in each group.The clinical efficacy and complication rate of the two groups were compared.Blood oxygen saturation,C-reactive protein(CRP),white blood cell count(WBC),interleukin-6(IL-6),malondialdehyde(MDA),myeloperoxidase(MPO)and superoxide dismutase(SOD)levels were compared between the two groups before and after treatment.Results The total response rate was higher in the HFNC group(92.50％)than that in the NIPPV group(75.00％)(P＜0.05).After treatment,oxygen saturation in arterial blood(SaO2),arterial partial oxygen pressure(PaO2)and arterial carbon dioxide(PaCO2)were lower than those in the NFNC group and before treatment(P＜0.05).The levels of CRP,IL-6 and WBC in HFNC group after treatment were lower than those in NIPPV group and before treatment(P＜0.05).MDA and MPO in HFNC group after treatment were lower than those in NIPPV group and before treatment,and SOD in HFNC group was higher than that in NIPPV group and before treatment(P＜0.05).The complication rate of HFNC group was lower than that of NIPPV group(P＜0.05).Conclusion HFNC treatment can improve the blood gas function of AECOPD patients with Ⅱ-RF,reduce the inflammatory state of patients,reduce the oxidative stress of the body,improve the comfort of patients,reduce the incidence of complications,and promote the rapid recovery of patients.
type Ⅱ respiratory failurehigh-flow nasal cannula oxygen therapynon-invasive positive pressure ventilationacute exacerbation of chronic obstructive pulmonary disease
万方数据
维普
