Effect of Modified Prone Position Ventilation on Respiratory Function and Prognosis in Patients with Acute Respiratory Distress Syndrome
Objective To investigate the effect of modified prone position ventilation on hemodynamics,respiratory dynamics and prognosis in patients with acute respiratory distress syndrome(ARDS).Methods Ninety-eight ARDS patients admitted to the First Affiliated Hospital Of Henan University from March 2020 to June 2022 were selected as the study objects and divided into group A and group B by random number table method.A randomized and prospective parallel controlled clinical study was conducted to evaluate the effects of different ventilation methods in ARDS patients.Among them,52 patients in group A received modified prone position ventilation and 46 patients in group B received traditional prone position ventilation.Hemodynamics[heart rate(HR),mean arterial pressure,and central venous pressure],respiratory dynamic indexes[airway resistance,static compliance(Cst)],oxygenation index and abdominal pressure were compared between the two groups before and after intervention.The incidence of adverse events was compared between the two groups.All patients were followed up for 3 months,and the mortality was compared between the two groups.Results(1)The mechanical ventilation time of group A was lower than that of group B,and the success rate of weaning was higher than that of group B(P＜0.05).(2)After intervention,HR of patients in both groups increased compared with that before intervention,the difference before and after intervention was statistically significant(P＜0.05).(3)After intervention,the level of Cst in the two groups was higher than that before intervention,and the level of Cst in group A was higher than that in group B,the difference before and after intervention was statistically significant(P＜0.05).(4)After intervention,abdominal pressure of the two groups were increased compared with those before treatment,and group A was lower than in group B,the difference before and after intervention was statistically significant(P＜0.05).(5)The total incidence of adverse events in group A(7.69％,4/52)was lower than that in group B(23.91％,11/46)(P＜0.05).(6)After 3 months of follow-up,the mortality of group A(23.08％,12/52)was lower than that of group B(43.48％,20/46)(P＜0.05).Conclusion The modified prone position ventilation can improve the hemodynamics,respiratory dynamics and related indexes of ARDS.The incidence of adverse events is low and the prognosis is good,which is worthy of clinical reference.
modified prone position ventilationacute respiratory distress syndromestatic complianceoxygenation indexabdominal pressureprognosis
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