Effect and Predictive Value of Serum sCD163,CK18,25-(OH)D3 on the Risk of Nosocomial Infection in Cirrhosis Patients with Esophageal Variceal Bleeding
Objective To investigate the impact and predictive value of serum soluble hemoglobin scavenger receptor differentiation-163(sCD163),cytokeratin 18(CK18),and 25-hydroxyvitamin D3[25-(OH)D3]on the risk of hospital infection cirrhosis patients with esophageal variceal bleeding(EVB).Methods A total of 114 cirrhosis patients with EVB admitted to Nanyang Central Hospital from February 2021 to February 2023 were selected.They were divided into infected group(36 cases)and non-infected group(78 cases)based on whether hospital infection occurred within 10 days of admission.The serum levels of sCD163,CK18,and 25-(OH)D3 were compared between two groups,the correlation and influencing factors between serum sCD163,CK18,and 25-(OH)D3 levels at admission for the nosocomial infection were analyzed,and the predictive value of combined detection of serum sCD163,CK18,and 25-(OH)D3 levels at admission for the nosocomial infection in cirrhosis patients with EVB was evaluated.Results At admission,the serum levels of sCD163 and CK18 in the infected group were higher than those in the non-infected group,while the level of 25-(OH)D3 was lower than the non-infected group(P＜0.05).The levels of serum CD163 and CK18 at admission were positively correlated with the nosocomial infection,while the level of 25-(OH)D3 was negatively correlated with the nosocomial infection(P＜0.05).The serum sCD163(＞5.16 mg·L-1)and CK18(＞14.25 μg·L-1)levels on admission were risk factors for nosocomial infection,and 25-(OH)D3(＞8.62 μg·L-1)level was protective factors for nosocomial infection.The area under curve of serum sCD163,CK18,25-(OH)D3 combined to predict nosocomial infection in patients with EVB was higher than that of each single index(P＜0.05).Conclusion The serum levels of sCD163,CK18 and 25-(OH)D3 in cirrhosis patients with EVB are associated with nosocomial infection and are independent risk factors for nosocomial infection.
万方数据
