Anesthetic Effect of Opioid-Free Anesthesia Combined with Epidural Anesthesia in Laparoscopic Cholecystectomy
Objective To explore the anesthetic effect of opioid-free anesthesia combined with epidural anesthesia in laparoscopic cholecystectomy.Methods A total of 78 patients who underwent laparoscopic cholecystectomy in the Second People's Hospital of Anyang from January 2021 to January 2023 were selected as the study subjects.The patients were randomly divided into study group(39 cases)and control group(39 cases).The control group received opioid-free anesthesia,while the study group received opioid-free anesthesia on the basis of epidural anesthesia.The anesthesia time,extubation time and awake time of the two groups of patients were recorded.The heart rate and mean arterial pressure were compared between two groups at four time points:before anesthesia,5 minutes after intubation,5 minutes after pneumoperitoneum and 5 minutes after extubation.The blood glucose and cortisol levels of the two groups of patients were compared before and after surgery.The Ramsay sedation scale was used to evaluate the sedative effect of patients at the 4th,8th,and 12th hours after surgery,and the visual analogue score(VSA)was used to evaluate the degree of postoperative pain.Results There was no statistically significant difference in anesthesia time between the two groups(P＞0.05),and the extubation time and awake time in the study group were shorter than those in the control group(P＜0.05).Five minutes after intubation,the heart rate and mean arterial pressure of patients in the study group were lower than those in the control group(P＜0.05).At other time points,there was no statistically significant difference between the two groups in heart rate and mean arterial pressure(P＞0.05).After pneumoperitoneum,compared with the control group,the blood glucose and cortisol levels in the study group were decreased(P＜0.05).At 4,8 and 12 hours after surgery,compared with the control group,the Ramsay score in the study group was increased,while the VAS score was decreased(P＜0.05).Conclusion Opioid-free anesthesia combined with epidural anesthesia can inhibit the stress response of patients during surgery,maintain the hemodynamic stability of patients,improve the sedative and analgesic effects,it can be widely used in clinical practice.
万方数据
维普
