Relationship Between Serum Parathyroid Hormone Expression and Myocardial Remodeling in Patients with Chronic Heart Failure
Objective To analyze the relationship between serum parathyroid hormone(PTH)and myocardial remodeling in patients with chronic heart failure(CHF),and to explore preventive targets for myocardial remodeling.Methods A total of 120 CHF patients admitted from March 2021 to February 2023 were selected as the study subjects.Left ventricular mass index and left atrial volume index were calculated based on the results of echocardiography.According to the calculation results,patients with myocardial remodeling were included in the myocardial remodeling group and those without myocardial remodeling were included in the non-remodeling group.On the day of admission,serum PTH was tested and general clinical data of patients were collected.Logistic regression was used to test the effect of serum PTH on myocardial remodeling in CHF patients.Results A total of 120 CHF patients were selected for this study,with a serum PTH detection result of(38.25±5.66)pmol·L-1 and a myocardial remodeling rate of 30.83％.The proportion of New York Heart Association(NYHA)grade Ⅲ and Ⅳ,and serum PTH and plasma N-temrina pro-barin natriuretic peptide(NT-proBNP)of patients with CHF combined with myocardial remodeling were higher than those of non-remodeling patients,and left ventricular ejection fraction(LVEF)was lower than that of non-remodeling patients(P＜0.05).Logistic regression analysis showed that NYHA Ⅲ,Ⅳ,decreased LVEF and increased serum PTH expression increased the risk of myocardial remodeling in CHF patients(P＜0.05).Receiver operating characteristic curve was drawn.The area under the curve of serum PTH in evaluating myocardial remodeling in CHF patients was 0.797.When serum PTH expression≥36.875 pmol·L-1,myocardial remodeling in CHF patients could be considered.Conclusion The expression of serum PTH is up-regulated in CHF patients with myocardial remodeling,and the up-regulation of serum PTH expression leads to an increased risk of myocardial remodeling in CHF patients.
万方数据
维普
