Correlation Between Uterine Artery Blood Flow Parameters,Serum IL-6,IFN-γ Levels and Pregnancy Outcomes in Patients with Recurrent Abortion
Objective To investigate the correlation between uterine artery flow parameters[pulse index(PI),peak end-systolic/end-diastolic flow rate(S/D),resistance index(RI)],serum interleukin-6(IL-6)and interferon-γ(IFN-γ)levels and pregnancy outcomes in patients with recurrent abortion.Methods A total of 147 early pregnant women with a history of recurrent abortion who were admitted to the hospital from January 2022 to April 2023 were selected as the study group,and they were divided into bad group and good group based on whether adverse pregnancy outcomes have occurred,and 74 pregnant women without a history of abortion were selected as the control group.Serum levels of IL-6,IFN-γ and uterine artery blood flow parameters were compared between the two groups at admission.The general data,serum IL-6,IFN-γ levels and uterine artery blood flow parameters of bad group and good group were compared,and the risk factors affecting adverse pregnancy outcomes were analyzed by logistic regression and the correlation was analyzed by Pearson.Results The serum IL-6 levels in the study group and the bad group were lower than those in the control group and the good group,and the serum IFN-γ levels,RI,PI and S/D values in the two groups were higher than those in the control group and the good group(P＜0.05).The values of progesterone,estradiol and β-human chorionic gonadotropin(β-HCG)in the good group were higher than those in the bad group(P＜0.05).IL-6,IFN-γ levels,RI,PI,S/D,progesterone,estradiol and β-HCG were all risk factors for adverse pregnancy events(P＜0.05).IL-6 was positively correlated with progesterone,estradiol and β-HCG,while IFN-γ,RI,PI and S/D were negatively correlated with progesterone,estradiol and β-HCG(P＜0.05).Conclusion There is a correlation between the parameters of uterine arterial hemodynamics,serum IFN-γ and IL-6 levels and the pregnancy outcome of recurrent abortion patients.
万方数据
维普
