Prognostic Value of Combined Serum Fractalkine,sICAM-1 and IL-6 Levels in Predicting the Prognosis of Patients Who Underwent Stenting Combined with Aspiration of Thrombus for Acute Occlusion of Large Intracranial Vessels
Objective To investigate the correlation between serum fractalkine,soluble inter cellular adhesion molecule-1(sICAM-1)and interleukin-6(IL-6)changes and the prognosis of neurological function in patients with acute intracranial great vessel occlusion stent combined with thrombolysis.Methods A total of 136 patients with acute intracranial great vessel occlusion who received stent combined thrombectomy in Zhumadian Central Hospital from May 2020 to October 2022 were selected as subjects.According to the modified Rankin scale score 3 months after surgery,they were divided into poor prognosis group(62 cases)and good prognosis group(74 cases).Serum levels of fractalkine,sICAM-1 and IL-6 were compared between the two groups,and the correlation between serum levels of fractalkine,sICAM-1 and IL-6 and prognosis were analyzed.Partial regression analysis was performed to analyze the influencing factors of poor prognosis in patients with acute intracranial vascular occlusion.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum fractalkine,sICAM-1 and IL-6 combined detection in patients with acute occlusion of great vessels,and to analyze the risk of poor prognosis in patients with acute occlusion of intracranial great vessels at different levels.Results The serum levels of fractalkine,sICAM-1 and IL-6 in the poor prognosis group were higher than those in the good prognosis group one month after surgery(P＜0.05).Serum levels of fractalkine,sICAM-1 and IL-6 at 1 month after surgery were positively correlated with the prognosis(P＜0.05).Logistic regression analysis showed that,serum fractalkine(＞100.26 μg·L-1),sICAM-1(＞45.20 μg·L-1),IL-6(＞65.95 ng·L-1)1 month after surgery were risk factors for poor prognosis in patients with acute intracranial vascular occlusion(P＜0.05).ROC analysis results showed that the area under the curve of serum fractalkine,sICAM-1 and IL-6 combined to predict poor prognosis in patients with acute intracranial vascular occlusion 1 month after surgery were 0.775.The best prediction sensitivity and specificity were 88.71％and 66.22％,respectively,which were higher than those predicted by single index(P＜0.05).Risk analysis showed that the patients with high levels of serum fractalkine,sICAM-1 and IL-6 1 month after surgery had a risk of poor prognosis,which was 2.373,2.148,1.820 times higher than those with low levels,respectively(P＜0.05).Conclusion Fractalkine,sICAM-1 and IL-6 are involved in the progression of acute intracranial vascular occlusion,and have high efficacy in predicting postoperative prognosis.
acute intracranial vascular occlusionprognosisfractalkinesoluble inter cellular adhesion molecule-1interleukin-6
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维普
