Correlation Analysis and Clinical Significance of Serum CTRP9,TGF-β2,ANGPTL3 Levels with Diabetic Retinopathy
Objective To investigate the correlation and clinical significance of serum C1q tumor necrosis factor-related protein 9(CTRP9),transforming growth factor-β2(TGF-β2),angiopoietin-like protein 3(ANGPTL3)levels with diabetic retinopathy(DR).Methods A total of 100 patients with DR Admitted to the hospital from September 2021 to September 2023 were retrospectively selected,including 39 cases of proliferative diabetic retinopathy(PDR)and 61 cases of non-proliferative diabetic retinopathy(NPDR),which were included in the PDR group and NPDR group,and 50 cases of diabetic patients without retinopathy during the same period were included in the control group.The serum levels of CTRP9,TGF-β2 and ANGPTL3 in the 3 groups were compared,and the correlation between serum indicators and the severity of DR disease and the diagnostic value of combined detection were analyzed,and the risk of DR in patients with different levels of each indicator was analyzed.Results The levels of CTRP9,TGF-β2 and ANGPTL3 in 3 groups were compared,the PDR group＞the NPDR group＞the control group,and the levels of each index were positively correlated with the severity of DR Disease(P＜0.05).At admission,the area under the curve of serum CTRP9,TGF-β2 and ANGPTL3 in the combined diagnosis of DR was 0.899,the best diagnostic sensitivity was 91.00％,the best diagnostic specificity was 88.00％,and the Yodon index was 0.790.The risk of DR in patients with high levels of each index was 1.419 times,1.239 times,1.381 times higher than that in patients with low levels(P＜0.05).Conclusion CTRP9,TGF-β2 and ANGPTL3 are all abnormally high expressed in the serum of DR patients,and the levels of each indicator are positively correlated with the severity of the disease,and the combined detection has certain diagnostic value for DR,and can be used as an auxiliary indicator for clinical diagnosis and evaluation of the disease.
C1q tumor necrosis factor-related protein 9transforming growth factor-β2angiopoietin-like protein 3diabetic retinopathy
万方数据
维普
