Effects of Topiramate Combined with Betahistine Mesylate in Patients with Peripheral Vertigo
Objective To explore the effects of topiramate combined with betahistine mesylate in patients with peripheral vertigo.Methods Eighty patients with peripheral vertigo were selected and randomly divided into control group(40 cases,treated with betahistine mesylate)and study group(40 cases,treated with betahistine mesylate and topiramate).The clinical efficacy,relief time of symptoms(vertigo,nausea and vomiting),anxiety and depression index,serum S100B protein(S100B),myelin space protein(MBP),brain-derived neurotrophic factor(BDNF)levels before and after treatment,and the incidence of adverse reactions were compared.Results Compared with the control group,the clinical effective rate was higher,the symptom relief time was shorter,the index of anxiety,depression,and the S100B,MBP levels were lower and the BDNF level was higher in the study group(P＜0.05).There was no statistically difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Topiramate combined with betahistine mesylate in the treatment of patients with peripheral vertigo can effectively relieve clinical symptoms,reduce anxiety and depression,and has high safety.
万方数据
维普
