Effects of Bushen Huazhuo Huoxue Decoction Combined with Memantine Hydrochloride on Cerebral Hemodynamics and Cognitive Function in Patients with Vascular Dementia
Objective To explore the effects of Bushen Huazhuo Huoxue Decoction combined with memantine hydrochloride on cerebral hemodynamics and cognitive function in patients with vascular dementia.Methods A total of 62 patients with vascular dementia confirmed in the hospital were enrolled as the research objects from June 2019 to April 2022.Patients were input into the computer system,random number sorting,the serial number odd included in the control group(31 cases)for memantine hydrochloride treatment,the serial number even included in the observation group(31 cases)for Bushen Huazhuo Huoxue Decoction combined with memantine hydrochloride treatment.All were treated for 6 courses of treatment(4 weeks/course).The response rate of treatment,cerebral hemodynamics indexes[mean flow velocity of anterior cerebral artery(Vanterior),mean flow velocity of middle cerebral artery(Vmiddle),mean flow velocity of posterior cerebral artery(Vposterior)],cognitive function[scores of Montreal cognitive assessment scale(MOCA)and mini-mental state examination(MMSE)],TCM symptoms[scale for the differentiation of syndromes of vascular dementia(SDSVD)]and serum indexes[brain-derived neurotrophic factor(BDNF),neuron-specific enolase(NSE),nerve growth factor(NGF)]before and after treatment,and adverse reactions in the two groups were compared.Results After treatment,total response rate of observation group was higher than that of control group(P＜0.05).After treatment,Vanterior,Vmiddle,Vposterior,MOCA score,MMSE score,BDNF and NGF were higher in observation group than control group(P＜0.05),while SDSVD score and NSE were lower in observation group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The application effect of Bushen Huazhuo Huoxue decoction combined with memantine hydrochloride is good in patients with vascular dementia,which can effectively improve cerebral hemodynamics,clinical symptoms,nerve function and cognitive function,with good safety.
Bushen Huazhuo Huoxue decoctionmemantine hydrochloridevascular dementiacerebral hemodynamicscognitive function
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维普
