Correlation Between Abdominal Visceral Fat and Lumbar Vertebral Bone Mineral Density in Patients with Primary Aldosteronism
Objective To explore the relationship between abdominal visceral fat distribution and bone mineral density(BMD)of lumbar spine in patients with primary aldosteronism(PA).Methods A total of 54 PA patients who diagnosed in the First Affiliated Hospital of Zhengzhou University from January 2017 to February 2021 were analyzed retrospectively.Quantitative CT(QCT)was used to measure the BMD value of L1-3.The total abdominal fat area(TFA),subcutaneous fat area(SFA)and visceral fat area(VFA)at the level of L2 were measured as well.According to the BMD value,the patients were divided into two groups:group A(osteopenic and osteoporosis group,24 cases)and group B(normal bone mass group,30 cases).Results Compared to group B,age,VFA,triglyceride and the ratio of orthostatic plasma aldosterone concentration(PAC)to plasma renin activity(PAC)was higher in group A,while orthostatic plasma renin levels was lower(P＜0.05).The correlation analysis showed that BMD of lumbar spine was negatively correlated with age(r=-0.521,P＜0.05)and VFA(r=-0.373,P＜0.05).Multiple linear regression analysis showed that VFA was still negatively correlated with VFA after controlling for age(P＜0.05).Further research showed that PA patients with increased VFA had lower BMD than the non-increased VFA(P＜0.05).Conclusion PA patients with increased VFA are more likely to present with low bone mass,and increased VFA may be a risk factor for decreased BMD in PA patients.
primary aldosteronismbone mineral densityvisceral fat areaquantitative CT
万方数据
维普
