Factors Influencing the Prognosis of Corona Virus Disease 2019 Related Acute Respiratory Distress Syndrome by Veno-Venous Extracorporeal Membrane Oxygenation
Objective To identify the prognostic factors for patients with severe acute respiratory distress syndrome(ARDS)resulting from corona virus disease 2019(CO VID-19)treated with veno-venous extracorporeal membrane oxygenation(V-V ECMO).Methods A retrospective study was conducted.The clinical data from 57 patients with severe ARDS due to COVID-19 who underwent V-V ECMO treatment in the Second Affiliated Hospital of Zhengzhou University from December 10,2022 to April 30,2023 were collected and analyzed.Patients were categorized into survival and non-survival groups based on their 30-day post-discharge survival status.Demographic information,clinical indicators,medication courses,hypertension,diabetes and inflammation closely associated with COVID-19 were compared between the two groups.Potential factors affecting prognosis and survival rate were identified.Through receiver operating characteristic(ROC)curve analysis and logistic multivariate analysis,the factors that affected the prognosis of patients with severe ARDS receiving V-V ECMO treatment in COVID-19 was identified.Results Among 57 patients,19 patients(33.3％)survived,while 38 patients(66.7％)did not.After 48 hours of use of V-V ECMO,there was a statistically difference between the two groups in terms of lactate(Lac),interleukin-6(IL-6)and the types of antibiotics used(P＜0.05).Diabetes and hypertension had no impact on the survival rate of patients,but diabetes had impact on the partial pressure of carbon dioxide of patients after V-V ECMO treatment(P＜0.05).Conclusion Antibiotic types and diabetes influence the outcomes of V-V ECMO treatment in severe ARDS patients with COVID-19.Lac and IL-6 was the risk factors affecting the prognosis of patients.
万方数据
维普
