Effect of Combined Hyperparathyroidism on Major Cardiovascular Adverse Events in Patients with Myocardial Infarction After Interventional Therapy
Objective To explore the impact of combined hyperparathyroidism(abbreviated as hyperparathyroidism)on major cardiovascular adverse events(MACE)in patients with acute myocardial infarction(AMI)after interventional therapy.Methods A total of 142 AMI patients who underwent percutaneous coronary intervention(PCI)treatment at the Fifth Clinical College of Henan University of Traditional Chinese Medicine(People's Hospital of Zhengzhou)from January 2019 to December 2021 were selected as the study subjects.According to the research purpose,relevant examinations were conducted on admission to evaluate whether the patient had concomitant hyperparathyroidism,and general clinical information was recorded.After treatment and discharge,a one-year follow-up was conducted to record the occurrence of MACE within one year,and to analyze the impact of concomitant hyperparathyroidism on MACE in AMI patients after interventional treatment.Results This study included a total of 142 patients with AMI intervention treatment,2 patients were lost during follow-up,1 patient had poor compliance during the trial,1 patient voluntarily requested to withdraw from the study,and ultimately 138 patients completed the trial.Among them,32 patients developed sarcopenia,with an incidence rate of approximately 23.19％.There was no statistical significant difference between the two groups in terms of gender,age,body mass index,basic disease history,smoking history,alcohol consumption history,hemoglobin(Hb),white blood cell count(WBC),red blood cell count(RBC),platelet count(PLT),QT interval,and Tp-Tec(P＞0.05).The levels of N-temrina pro-barin natriuretic peptide(NT-proBNP),troponin Ⅰ,serum parathyroid hormone(PTH),and the proportion of concurrent hyperparathyroidism in the occurrence group were higher than those in the non-occurrence group(P＜0.05).Point two column correlation test was used,there was a positive correlation between patients with combined hyperparathyroidism and MACE after AMI intervention treatment(P＜0.05).A logistic regression model was constructed,the data showed that the combination of hyperparathyroidism,troponin Ⅰ,NT-proBNP and serum PTH all increased the risk of MACE in patients with AMI after interventional therapy(P＜0.05).Conclusion The combination of hyperparathyroidism is an independent influencing factor for MACE in patients with AMI after interventional therapy.When patients with hyperparathyroidism are treated with AMI,the risk of postoperative MACE is significantly increased.
万方数据
维普
