Expression of miR-150-5p in Breast Cancer Tissues and Its Clinical Significance
Objective To investigate the expression of microRNA-150-5p(miR-150-5p)in breast cancer tissues and its clinical significance.Methods A prospective cohort study was conducted to select 86 patients with breast cancer who were admitted to Luoyang Maternal and Child Health Hospital from December 2019 to May 2022.General data such as patient age,breast cancer family genetic history,tumor diameter,disease type,etc.were collected,and the level of miR-150-5p in cancer tissues and adjacent normal tissues of all patients was measured.Results The miR-150-5p level in cancer tissue was higher than that in normal tissue adjacent to cancer(P＜0.001).The tumor diameter size and proportion of stage Ⅲ-Ⅳin the high level group were higher than those in the low level group(P＜0.05).A total of 11 cases(12.79％)of recurrence and metastasis occurred in 86 patients with breast cancer,including 3 cases in the low level group and 8 cases in the high level group.Logistic regression analysis showed that the level of miR-150-5p would affect the recurrence and metastasis of breast cancer(P＜0.05).Conclusion The expression of miR-150-5p in breast cancer tissue is abnormally high,may be its one of the indicators of poor prognosis of patients.The level of miR-150-5p in cancer tissue is related to tumor diameter and stage.
breast cancermiR-150-5 precurrence and metastasistumor diameter
万方数据
维普
