Clinical Effect of Xinmerong Injection Combined with Bisoprolol Fumarate Tablet in the Treatment of Patients with Heart Failure Caused by Acute Myocardial Infarction
Objective To investigate the efficacy of Xinmailong injection combined with bisoprolol fumarate tablet in the treatment of patients with heart failure(HF)caused by acute myocardial infarction(AMI).Methods A total of 106 patients with HF caused by AMI admitted to Kaifeng Hospital of Traditional Chinese Medicine from May 2021 to August 2023 were selected and divided into two groups by random number table method,53 cases in each group.The control group was treated with bisoprolol fumarate tablet,and the experimental group was treated with Xinmerong injection combined with bisoprolol fumarate tablet.The clinical efficacy,safety and electrocardiograph parameters[mean normal RR interval standard deviation(SDNN),percentage of adjacent RR interval difference＞50 ms(PNN50),standard deviation of mean value of normal RR interval(SDANN)],inflammatory factors[interleukin-6(IL-6),hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)],myocardial damage related indicators[N-terminal B-type natriuretic peptide(NT-proBNP),creatine kinase isoenzyme(CK-MB),matrix metalloproteinase-9(MMP-9),transforming growth factor-β1(TGF-β1)],Quality of life[Minnesota heart failure quality of life scale(MLHFQ)score]before and after treatment were compared between the two groups.Results The total effective rate of experimental group was higher than that of control group(P＜0.05),and there was no difference in the adverse reaction rate between the two group(P＞0.05).Repeated measurement analysis showed that there were statistical differences in the intra-subject and inter-subject effects of SDNN,PNN50,SDANN,IL-6,hs-CRP,TNF-α,NT-proBNP,CK-MB,TGF-β1,MMP-9 and MLHFQ scores between the two groups(P＜0.05).After 1 and 2 weeks of treatment,SDNN,PNN50,SDANN in experimental group were higher those of control group,serum levels of IL-6,hs-CRP,TNF-α,NT-proBNP,CK-MB,TGF-β1,MMP-9 and MLHFQ score in experimental group were lower than those in the control group(P＜0.05).Conclusion Xinmailong injection combined with bisoprolol fumarate tablets can effectively reduce inflammatory response,inhibit myocardial fibrosis,alleviate myocardial injury,improve heart rate variability,and further enhance clinical efficacy for HF caused by AMI patients.
万方数据
维普
