Effect of Bifidobacterium Quadruplex Viable Tablets Combined with Azithromycin in the Treatment of Severe Pneumonia in Children and Its Influence on Pulmonary Ultrasound Score and Intestinal Flora
Objective To investigate the effects of bifidobacterium quadruplex viable tablets combined with Azithromycin in the treatment of severe pneumonia in children and the effects on pulmonary ultrasound scores and intestinal flora.Methods A total of 98 children with severe pneumonia admitted to Xinyang Central Hospital from February 2021 to February 2023 were selected as research objects,and divided into observation group and control group according to random number table method,49 cases in each group.The control group was treated with Azithromycin,and the observation group was treated with bifidobacterium tetrad combined with Azithromycin.The clinical efficacy,recovery of clinical symptoms,pulmonary ultrasound scores,inflammatory response indexes[interleukin-17(IL-17),soluble myeloid cell trigger receptor-1(sTREM-1),hypersensitive C-reactive protein(hs-CRP)],and intestinal flora indexes[enterobacterium,bifidobacterium,bacteroides]were compared between the two groups.Results The total effective rate of observation group(95.92％)was higher than that of control group(71.43％)(P＜0.05).After 8 days of treatment,the recovery time of heart rate,disappearance of lung rales,relief of dyspnea,recovery of body temperature,disappearance of lung shadow and relief of cough in observation group were shorter than those in control group(P＜0.05).After 8 days of treatment,the ultrasound scores of the observation group were lower than those of the control group(P＜0.05).After 8 days of treatment,the levels of IL-17,sTREM-1 and hs-CRP in observation group were lower than those in control group(P＜0.05).After 8 days of treatment,the number of enterobacter colonies in the observation group was less than that in the control group,and the number of bifidobacterium and bacteroides colonies was more than that in the control group(P＜0.05).Conclusion The combined application of bifidobacterium tetrad viable tablets and Azithromycin in the treatment of severe pneumonia in children is effective,which can effectively improve the inflammatory state of the body,maintain the balance of intestinal flora,reduce the lung ultrasound score,and promote the prognosis.
万方数据
维普
