Therapeutic Effect of Postoperative Application of Modified Shengmai Powder for Thyroid Cancer
Objective To analyze the efficacy of using Jiawei Shengmai San for postoperative treatment of thyroid cancer(TC).Methods Sixty cases postoperative TC patients from Zhengzhou First People's Hospital from January 2018 to December 2022 were selected and randomly divided into groups using a number table method,with 30 patients in each group.The control group was treated with conventional western medicine,while the observation group was treated with Jiawei Shengmai San for 3 months.The clinical efficacy,traditional Chinese medicine syndrome score,PI3K-AKT signaling pathway,thyroid hormones,and adverse reactions of the two groups were calculated.Results The total effective rate of the observation group was higher than that of the control group after 3 months of treatment(P＜0.05).After 1 month and 3 months of treatment,the scores of shortness of breath and unwillingness to speak,dry mouth and pharynx,fatigue and lack of strength,and sphoria with feverish sensation in chest,palms and soles of the observation group were lower than those of the control group(P＜0.05).After 1 month and 3 months of treatment,the levels of thyroid stimulating hormone,thyroglobulin antibodies and thyroid peroxidase antibody in the observation group were lower than those in the control group,and the levels of free triiodothyronine and free thyroxine,PI3Kpll0 and AKT1 mRNA and protein in peripheral blood mononuclear cells were higher than those in the control group(P＜0.05).Conclusion The application of Jiawei Shengmai San after TC surgery has a definite effect and helps to improve traditional Chinese medicine syndrome types and thyroid function.Its mechanism of action may regulate the PI3K-AKT signaling pathway and promote cell apoptosis.
万方数据
维普
