Relationship Between DBIL/TBIL Expression and Recurrence of Ultrasound-Guided Radiofrequency Ablation for Primary Carcinoma of Liver Patients
Objective To analyze the relationship between the ratio of direct bilirubin(DBIL)to total bilirubin(TBIL)in serum and the recurrence of patients with primary carcinoma of liver(PLC)treated with ultrasound guided radiofrequency ablation.Methods A total of 124 PLC patients who planned to undergo radiofrequency ablation treatment from March 2018 to February 2021 were selected as the research subjects.According to the research purpose,relevant indicators,including serum DBIL,TBIL,tumor markers,and general clinical data of the patients,were routinely tested before radiofrequency ablation treatment.Complete ablation of radiofrequency ablation was regarded as successful ablation,and recurrence within 2 years after successful ablation was regarded as the end point of follow-up.Cox regression was used to analyze the relationship between serum DBIL/TBIL and recurrence of ultrasound-guided radiofrequency ablation in patients with PLC.Results From March 2018 to February 2021,a total of 124 PLC patients were enrolled,with a one-time ablation success rate of 92.06％(116/126)and a recurrence rate of 21.55％(25/116).After radiofrequency ablation treatment,the number and diameter of tumors in recurrent patients were greater than those in non recurrent patients,while serum TBIL and DBIL were lower than those in non recurrent patients.The alpha fetoprotein and DBIL/TBIL ratio were higher than those in non recurrent patients(P＜0.05).The construction of Cox regression analysis showed that the number of tumors ≥ 3,tumor diameter,downregulation of serum TBIL expression,and an increase in DBIL/TBIL ratio led to an increased risk of recurrence in PLC patients after radiofrequency ablation treatment(P＜0.05).Receiver operating characteristic curve was drawn.The area under the curve of serum DBIL/TBIL ratio to predict recurrence after radiofrequency ablation in PLC patients was 0.776.When the DBIL/TBIL cutoff value reached 0.50,the highest sensitivity(0.920)and specificity(0.495)could be obtained.Conclusion The increase in serum DBIL/TBIL ratio leads to an increased risk of recurrence in PLC patients within 2 years after radiofrequency ablation treatment.Calculating the DBIL/TBIL ratio before ablation treatment can help predict the risk of recurrence.
primary carcinoma of liverradiofrequency ablation treatmentdirect bilirubintotal bilirubinrecurrence
万方数据
维普
