Effect of Aspirin on Sepsis:A Systematic Review and Meta-Analysis
Objective To study the comprehensive analysis of the effect of aspirin on the efficacy of sepsis by using a systematic evaluation method.Methods Systematically search PubMed,Embase,and The Cochrane Library databases to search for clinical studies on the effects of aspirin on the efficacy of sepsis patients.Based on pre-set inclusion and exclusion criteria,select articles that meet the inclusion criteria.The main outcome of the study was case fatality rate,and a random effects model and a fixed effects model were used,with odds ratio(OR)and weighted mean difference(WMD)as the effect measures.Each effect measure was represented by a 95％confidence interval(CI).The quality of included studies using the Newcastle Ottawa scale(NOS)was evaluated.The robustness of the sensitivity analysis evaluation results,funnel chart and Egger linear regression evaluation were included in the potential publication bias of the study.Stata 12.0 statistical software was used for data statistics and analysis.Results A total of 14 articles(148 002 patients with sepsis)were included in this study,of which 9 were cohort study,3 were randomized controlled studies and 2 were prospective studies.Aspirin can reduce the 30 day mortality rate,ICU mortality rate,and in-hospital mortality rate of sepsis patients(P＜0.05),but it cannot improve the incidence of organ failure in sepsis patients(P=0.308)and 90 day mortality rate(P=0.267).Conclusion Aspirin can reduce the 30 day mortality rate,ICU mortality rate,and in-hospital mortality rate of sepsis patients,but it cannot improve the incidence of organ failure in sepsis patients and 90 day mortality rate.
万方数据
维普
