Characteristics of Pulmonary Microbiota in Patients with CTD-ILD Combined with Pulmonary Infection and Their Impact on Pulmonary Fibrosis
Objective To investigate the characteristics of pulmonary microbiota in patients with connective tissue disease associated interstitial lung disease(CTD-ILD)combined with pulmonary infection and their impact on pulmonary fibrosis.Methods A total of 45 patients with CTD-ILD complicated with pulmonary infection treated in the hospital from February 2021 to May 2022 were selected as the observation group,while 45 patients with CTD-ILD without pulmonary infection were selected as the control group,the differences in lung function and high resolution CT(HRCT)pulmonary fibrosis score between the two groups were compared,and the distribution of pathogens in the observation group was analyzed.Results In the observation group,the percentage of forced vital capacity to the predicted value(FVC％pred),the percentage of forced expiratory volume in the first second to the predicted value(FEV1％pred),the percentage of carbon monoxide diffusion volume to the predicted value(DLCO％pred),forced vital capacity(FVC),maximum expiratory flow(MEF)and residual volume(RV)were lower than those of the control group(P＜0.05).The observation group had higher rates of patchy HRCT imaging and bronchiectasis compared to the control group(P＜0.05),while the CT fibrosis score was higher than that of the control group(P＜0.05).In the distribution of pathogenic bacteria in the observation group,Klebsiella pneumoniae and Pseudomonas aeruginosa were the main bacteria,accounting for 24.44％and 15.56％,respectively.Cytomegalovirus and human herpesvirus were detected in the virus,accounting for 11.11％and 6.67％,respectively.Candida albicans was detected in the fungus,accounting for 11.11％.The CT fibrosis score of patients aged≥60 years in the observation group was higher than that of patients aged＜60 years(P＜0.05).Conclusion Patients with CTD-ILD combined with pulmonary infection are mainly infected with bacteria.Compare with patients without pulmonary infection,patients with pulmonary infection has more severe pulmonary fibrosis.
connective tissue disease related interstitial lung diseasepathogenic bacteriapulmonary fibrosispulmonary infection
万方数据
维普
