Risk Factors and Risk Prediction Model Construction of Radiation-Induced Brain Injury in Nasopharyngeal Carcinoma Patients Undergoing Radiotherapy
Objective To explore the risk factors of radiation-induced brain injury in nasopharyngeal carcinoma patients undergoing radiation therapy,and to construct a risk prediction model.Methods Retrospective selection of 40 nasopharyngeal carcinoma patients who experienced radiation brain injury after radiotherapy at the Fifth Affiliated Hospital of Zhengzhou University from January 2021 to January 2022 as the incidence group,and 61 nasopharyngeal carcinoma patients who did not experience radiation brain injury after radiotherapy during the same period as the non incidence group.General data and clinical indicators of the two groups were collected.Logistic regression analysis was used to test the risk factors affecting radiation-induced brain injury in patients with nasopharyngeal carcinoma radiotherapy.At the same time,a risk prediction model was constructed based on the results of regression analysis.The receiver operating characteristic(ROC)curve was drawn to test the predictive value of the risk prediction model for radiation-induced brain injury in patients with nasopharyngeal carcinoma radiotherapy.Results There was statistical difference between the two groups of patients in terms of the highest bilateral temporal lobe irradiation dose,serum glial fibrillary acidic protein(GFAP),serum cyclooxygenase-2(COX-2),and plasma fibrinogen(Fib)levels(P＜0.05).Logistic regression analysis showed that high levels of bilateral temporal lobe maximum radiation dose,serum GFAP,serum COX-2,and plasma Fib levels were risk factors for radiation-induced brain injury in nasopharyngeal carcinoma radiotherapy patients(P＜0.05).The risk prediction model was constructed.The ROC internal validation showed that the area under the curve(AUC)was 0.911,the 95％CI of AUC was 0.851-0.972,the specificity was 0.967,the sensitivity was 0.775,and the Youden's statistic index was 0.742,P＜0.001.Conclusion The highest bilateral temporal lobe irradiation dose,serum GFAP,serum COX-2,and plasma Fib are risk factors that affect the occurrence of radiation-induced brain injury in nasopharyngeal carcinoma patients undergoing radiotherapy.
nasopharyngeal carcinomaradiation-induced brain injuryradiation therapyinfluencing factorsrisk prediction model
万方数据
维普
