Preoperative Expression of Ferritin in Patients with Traumatic Brain Injury and its Clinical Significance
Objective To analyze the expression level of serum ferritin(SF)in patients with traumatic brain injury before surgery,and explore its relationship with the patient's condition and prognosis.Methods A prospective study was conducted,116 patients with traumatic brain injury who underwent hematoma clearance and decompressive craniectomy at the 7th People's Hospital of Zhengzhou City from January 2022 to December 2022 were selected as the study subjects and were included in the traumatic brain injury group.According to the Glasgow coma scale(GCS),patients were divided into mild coma group,moderate coma group,and severe coma group.According to the Glasgow outcome scale(GOS)at one month after surgery,patients were divided into a good prognosis group and a poor prognosis group.In addition,50 healthy volunteers who underwent hospital health examinations were selected and included in the control group.Pearson correlation analysis was used to analyze the correlation between preoperative SF expression and GCS score and GOS score in patients with traumatic brain injury.At the same time,the receiver operating characteristic(ROC)curve was drawn to explore the predictive value of preoperative SF on the prognosis of patients with traumatic brain injury.Results Among the 116 patients with traumatic brain injury,37 had poor postoperative prognosis,accounting for 31.90％.There were 79 cases had a good prognosis,accounting for 68.10％.The SF level in the traumatic brain injury group was higher than that in the control group(P＜0.05).The SF levels of patients with different levels of coma were higher than those of the control group(P＜0.05).The SF of the severe coma group was higher than that of the mild coma group and the moderate coma group,and the serum SF of the moderate coma group was higher than that of the mild coma group(P＜0.05).The SF level in the poor prognosis group was higher than that in the good prognosis group and the control group(P＜0.05).The SF level in the good prognosis group was higher than that in the control group(P＜0.05).According to Pearson correlation analysis,preoperative SF expression was negatively correlated with GCS and GOS score(r＜0,P＜0.05).The ROC curve was plotted,and the results showed that the area under the curve(AUC)of preoperative SF expression predicting poor prognosis in patients with traumatic brain injury was greater than 0.7,which had certain predictive value.Conclusion Preoperative SF in patients with traumatic brain injury shows high expression,which is correlated with the severity and prognosis of the injury.Preoperative SF can be used as a reference indicator for evaluating the prognosis of patients with traumatic brain injury.
万方数据
维普
