Effect of Tirofiban Combined with Ticagrelor on Neurological Function and Recurrence in Patients with Acute Progressive Cerebral Infarction
Objective To explore the effect of tirofiban combined with ticagrelor on neurological function and recurrence in patients with acute progressive cerebral infarction.Methods A total of 108 patients with acute progressive cerebral infarction were selected from March 2021 to March 2023 and were divided into ticagrelor group(54 cases,conventional treatment combined with ticagrelor)and combined group(54 cases,conventional treatment combined with tirofiban and ticagrelor)according to the random number method.The neurological function[modified Rankin scale(mRS)and National Institutes of Health stroke scale(NIHSS)],living ability[activities of daily living(ADL)],cranial base hemodynamics[middle cerebral artery,anterior artery and vertebral artery],nerve injury markers[central nerve specific protein(S100-β),ubiquitin C-terminal hydrolase-L1(UCH-L1),neuron-specific enolase(NSE)],serum oxidative stress markers[reactive oxygen species(ROS),malondialdehyde(MDA),glutathione(GSH)],adverse drug reactions and recurrence rate were compared between the two groups.Results After treatment,mRS score and NIHSS score in the two groups were decreased(P＜0.05),and the scores in combined group were lower than those in ticagrelor group(P＜0.05).At discharge,the scores of physical life self-care and instrumental activities of daily living were increased in both groups(P＜0.05),and the scores in combined group were higher than those in ticagrelor group(P＜0.05).The blood flow velocities of middle artery,anterior artery and vertebral artery were risen in both groups after treatment(P＜0.05),and the velocities in combined group were faster than those in ticagrelor group(P＜0.05).After treatment,the levels of S100-β,UCH-L1,NSE,ROS,MDA and GSH were decreased in both groups(P＜0.05),and the levels in combined group were lower(P＜0.05).There was no statistically difference in the incidence and recurrence rates of adverse reactions between the two groups(P＞0.05).Conclusion Tirofiban combined with ticagrelor can improve neurological function,enhance daily living ability,alleviate cerebral nerve injury,and enhance cerebral blood flow in patients with acute progressive cerebral infarction,with few adverse reactions and low recurrence rate.
acute progressive cerebral infarctiontirofibanticagrelorneurological function
万方数据
维普
