Effect of Remimazolam on Hemodynamics and Postoperative Cognitive Function in Elderly Patients Undergoing Laparoscopic Cholecystectomy
Objective To explore the effects of remimazolam on hemodynamics and postoperative cognitive function in elderly patients undergoing laparoscopic cholecystectomy.Methods A total of 80 elderly patients who underwent laparoscopic cholecystectomy in Anyang People's Hospital from January 2021 to December 2022 were selected as the study objects,and were divided into observation group and control group by random number table method,with 40 cases in each group.The control group received midazolam for anesthesia induction,and the observation group received remimazolam for anesthesia induction.The types and doses of other anesthetic induction drugs were consistent between the two groups.The hemodynamics of the two groups were compared before anesthesia induction(T0),during endotracheal intubation(T1),skin resection(T2)and endotracheal extubation(T3).Using the mini mental state evaluation scale(MMSE)to evaluate cognitive function in two groups.Record the postoperative recovery time,tracheal extubation time,and anesthesia monitoring room stay time of two groups of patients.Results There was no statistically difference in hemodynamics such as HR and MAP between the two groups of patients at T0(P＞0.05),while HR and MAP were higher in the control group at T1-T3 compared to T0.HR and MAP in the observation group were lower than those in the control group at T,-T3(P＜0.05).There was an interaction between two groups of HR and anesthesia method at different time points(P＜0.05),while MAP did not have an interaction(P＞0.05).There was no statistically difference in preoperative MMSE scores between the two groups of patients(P＞0.05).At 24,48 and 72 hours postoperatively,MMSE scores decreased compared to preoperative levels,and the observation group had higher MMSE scores than the control group at these three time points(P＜0.05).There was an interaction between MMSE scores and anesthesia methods at various time points(P＜0.05).The postoperative recovery time,tracheal extubation time,and anesthesia monitoring room stay time of the observation group were all lower than those of the control group(P＜0.05).Conclusion Remazolam,as an anesthetic inducer,can alleviate intraoperative hemodynamic fluctuations in elderly patients undergoing laparoscopic cholecystectomy,promote postoperative recovery of cognitive function and anesthesia effect,and can be applied to induce general anesthesia in elderly patients.
remazolamlaparoscopic cholecystectomyelderlyhemodynamicscognitive function
万方数据
维普
