Retrospective Analysis of Clinical Characteristics and Clinical laboratory Results in Patients with IgG4-Related Diseases
Objective To explore the clinical characteristics and detection value of C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),complement 3(C3),complement 4(C4),immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM),immunoglobulin E(IgE)in IgG4-related diseases(IgG4-RD).Methods The clinical data and laboratory results of 52 patients diagnosed as IgG4-RD in the First Affiliated Hospital of Zhengzhou University from January 2020 to July 2022 were retrospectively analyzed,and 56 healthy people matched in age and sex in the same period were taken as the healthy control group.The expression differences of CRP,ESR,C3,C4,IgA,IgG,IgM and IgE between the two groups were compared.Pearson correlation analysis was used to evaluate the correlation among the indicators.Results Among 52 patients with IgG4-RD,pancreas-gallbladder-liver were the most common involved organs,followed by head,lacrimal glands and salivary glands.Forty patients(76.9％)showed more than two organs involvement,and only 12 cases(23.1％)showed one single organ involvement.The abnormal rates of CRP,ESR,C3,C4,IgG and IgE were 44.9％,67.4％,47.5％,32.5％,62.5％and 83.3％respectively.Compared with the healthy control group,the levels of CRP,ESR,IgG and IgE in IgG4-RD group were increased(P＜0.001).While the levels of C3 and C4 were markedly decreased(P＜0.001).Levels of IgA and IgM showed no significant difference between the two groups(P＞0.05).Correlation analysis showed IgE was positively correlated with IgG4(r=0.433,P=0.034)and negatively correlated with C4(r=-0.457,P=0.028).Conclusion The clinical manifestations of IgG4-RD lack specificity and often involve multiple organs.Detection of CRP,ESR,C3,C4,IgA,IgG,IgM and IgE exhibited certain reference value for the diagnosis of IgG4-RD and IgE was closely related with the occurrence and development of IgG4-RD.
NETL
NSTL
万方数据
