Relationship Between Th1/Th2 Cytokines and the Prognosis of Laparoscopic Surgery for Primary Liver Cancer
Objective To investigate the relationship between Th1/Th2 cytokines and the prognosis of patients undergoing laparoscopic surgery for primary liver cancer.Methods A prospective study was conducted to select 92 patients with primary liver cancer who planned to undergo laparoscopic surgery in Xinyang Central Hospital from December 2018 to December 2021.The expression level of Th1 cytokines[interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α)],Th2 cytokines[interleukin-4(IL-4),interleukin-10(IL-10)]and the frequency of Th1 and Th2 cells in peripheral blood were measured before and 1 week after operation,and the Th1/Th2 ratio was calculated.All patients were followed up for one year to count the prognosis,observe the changes of Th1/Th2 cytokines in patients with different prognosis,and analyze the relationship between them and the prognosis using point binary correlation.Results Compared with that before operation,IFN-γ,TNF-α,IL-4,IL-10,Th1 cell frequency,Th2 cell frequency and Th1/Th1 in all patients were lower one week after operation(P＜0.05).During the one-year follow-up,23 of 92 patients had recurrence,metastasis and death,and were included in the poor prognosis group.There were no differences in IFN-γ,IL-10,Th1 cell frequency and Th2 cell frequency between the two groups before surgery(P＞0.05).The TNF-α and Th1/Th2 levels in the good prognosis group were higher before and 1 week after surgery than those in the poor prognosis group,and IL-4 levels were lower than those in the poor prognosis group(P＜0.05).Point two-column correlation analysis showed that the prognosis of laparoscopic primary liver cancer was positively correlated with IL-4 before and after surgery(r＞0,P＜0.05),and negatively correlated with TNF-αand Th1/Th2 before and after surgery(r＜0,P＜0.05).Conclusion The expression level of Th1/Th2 cytokines decreases in patients with primary liver cancer after laparoscopic surgery,and this abnormal low expression is negative correlation to the patient's surgical prognosis.
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