Effect of Th1/Th2 Cell Expression on the Treatment Outcome of Multidrug-Resistant Pulmonary Tuberculosis Patients
Objective To investigate the effect of helper T cell 1(Th1)/helper T cell 2(Th2)cell expression on the treatment outcome of multidrug-resistant pulmonary tuberculosis(MDR-TB)patients.Methods Clinical data of 92 MDR-TB patients admitted to Nanyang Central Hospital from January 2019 to September 2022 were retrospectively included.All patients received the combined treatment of levofloxacin,bedazoline,linezolid,clofazimine and cycloserine,and the intensive treatment cycle was 6 months.According to the outcome of intensive treatment,patients were divided into a good outcome group(74 cases)and a poor outcome group(18 cases).The general data of the two groups were compared with the expression of Th1 and Th2 cells and other laboratory indicators measured before treatment,and the effect of Th1/Th2 cell expression on the treatment outcome of patients was analyzed.Results The proportion of smoking history and Th2 in the poor outcome group were higher than those in the good outcome group,while Th1 and Th1/Th2 were lower than those in the good outcome group(P＜0.05).According to point two column correlation analysis,the expression of Th1,Th2,and Th1/Th2 cells was related to the treatment outcome of MDR-TB patients.The receiver operating characteristic(ROC)curve was drawn.The results showed that the area under the curve(AUC)of Th1,Th2 and Th1/Th2 cell expression in predicting the treatment outcome of MDR-TB patients was 0.827,0.813 and 0.883,respectively,and Th1/Th2 had the highest predictive value.Conclusion The expression of Th1/Th2 cells can have an impact on the treatment outcome of MDR-TB patients,and the higher the value,the higher the incidence of poor treatment outcome.
multidrug-resistant pulmonary tuberculosishelper T celloutcome
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