Predictive Value of NT-proBNP/BNP Ratio for Major Adverse Cardiovascular Events In-hospital in Patients with Acute ST-segment Elevation Myocardial Infarction After PCI
Objective To investigate the predictive value of N-terminal pro-brain natriuretic peptide/brain natriuretic peptide(NT-proBNP/BNP)ratio for major adverse cardiac events(MACE)in-hospital in patients with acute ST-segment elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI).Methods Ninety cases with acute STEMI who underwent PCI treatment and were admitted to Xingyang People's Hospital from November 2021 to November 2022 were selected as the research objects.According to whether MACE in-hospital occurred after PCI,they were divided into MACE group(17 cases)and MACE-free group(73 cases).Automatic chemiluminescence immunoassay was used to detect NT-proBNP level,and radioimmunoassay was used to detect BNP level.The general data and NT-proBNP/BNP ratio of the two groups were compared,and the ROC was used to evaluate the predictive value of NT-proBNP/BNP on the in-hospital MACE of STEMI patients after PCI.The related factors of MACE were explored by multivariate logistic regression.Results The incidence of MACE in hospital in 90 patients after PCI was 18.88％(17/90).The diabetic history rate,heart rate,white blood cell,cardiac troponin I,myoglobin,and creatine kinase-MB peaks in the MACE group after PCI were higher than those in the MACE-free group,and LVEF was lower than in the MACE-free group(P＜0.05).NT-proBNP,BNP and NT-proBNP/BNP in the MACE group after PCI were all higher than those of MACE-free group(P＜0.05).The AUC of NT-proBNP/BNP predicting MACE in-hospital in acute STEMI patients after PCI was 0.856,and the sensitivity was 82.3％,and the specificity was 84.9％.The high expression of NT-proBNP/BNP was a risk factor for the occurrence of MACE in-hospital in patients with acute STEMI after PCI(P＜0.05).Conclusion The high expression of NT-proBNP/BNP is a risk factor for MACE in acute STEMI patients after PCI.It may be used as a predictor of in-hospital MACE in acute STEMI patients after PCI.
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