Protein C,Protein S and Antithrombin Ⅲ Levels in Pregnant Women with Diabetes and Their Relationship with Gestational Age
Objective To investigate the levels of protein C(PC),protein S(PS)and antithrombin Ⅲ(ATⅢ)in patients with gestational diabetes mellitus(GDM),and their relationship with gestational age.Methods A total of 232 GDM pregnant women who visited to the hospital from January 2019 to March 2023 were selected as the observation group,while 268 normal pregnant women who underwent pregnancy tests at the hospital during the same period were randomly selected as the control group.The general information and PC,PS and AT Ⅲ levels of the two groups were compared and analyzed.The observation group and the control group were divided into mid-pregnancy and late-pregnancy according to gestational weeks,and the levels of PC,PS and AT Ⅲ between the observation group and the control group in mid-pregnancy and late-pregnancy were compared,respectively.The correlation between PC,PS and AT Ⅲ levels and gestational age was analyzed through correlation analysis.Results Compared with the control group,the PS and PC levels of the observation group were reduced(P＜0.05),but the AT Ⅲ level has no statistical differences(P＞0.05).The levels of PC and AT Ⅲ in GDM patients were negatively correlated with gestational age(r=-0.156,-0.134,P＜0.05).Conclusion The levels of PS and PC in GDM patients decrease,and as the gestational age increases,the levels of PC,PS and AT Ⅲ decrease.Early intervention should be taken to reduce the risk of thrombosis.
万方数据
维普
