Expression and Clinical Significance of Serum HBV-DNA in Chronic Hepatitis B Patients Receiving Antiviral Treatment with Nucleoside Analogues and Nucleotide Analogues
Objective To explore the expression and clinical significance of hepatitis B virus deoxyribonucleic acid(HBV-DNA)in chronic hepatitis B(CHB)patients undergoing antiviral therapy with nucleoside analogues and nucleotide analogues(NAs).Methods A retrospective analysis was conducted on the clinical data of 83 CHB patients treated with NAs antiviral therapy at Henan Provincial People's Hospital from January 2021 to October 2022.According to the serological response criteria,they were divided into response group(46 cases)and non-response group(37 cases).Baseline data and serum HBV-DNA levels before treatment,at 3,6 and 12 months of treatment were compared between two groups.The receiver operating characteristic(ROC)curve was drawn,and the area under the curve(AUC)was used to test the predictive value of serum HBV-DNA for non-response to NAs antiviral therapy in CHB patients.Results Before treatment,there was no statistical difference in HBV-DNA between the response group and the non-response group(P＞0.05).The HBV-DNA of the two groups showed a gradual downward trend from before treatment to 12 months after treatment.The inter group,time point,and interaction effects had statistical significance(P＜0.05).The ROC curve showed that the predictive value of HBV-DNA for non-response to NAs antiviral therapy in CHB patients was low at 3 months of treatment(AUC=0.694,P=0.002),while HBV-DNA had a certain predictive value for non-response to NAs antiviral therapy in CHB patients at 6 months of treatment(AUC=0.751,P＜0.001).Conclusion The expression of serum HBV-DNA showed significant changes in CHB patients before and after NAs antiviral therapy,and serum HBV-DNA at 6 months of treatment can serve as a predictive indicator of non-response to antiviral therapy.
chronic hepatitis Bnucleoside analogues and nucleotide analoguesantiviral therapyhepatitis B virus deoxyribonucleic acid
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