The Expression and Clinical Significance of D-dimer to Fibrinogen Ratio in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Objective To investigate the expression and clinical significance of D-dimer to fibrinogen ratio(DFR)in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods Patients with acute exacerbation of COPD admitted to the hospital from February 2021 to February 2023 were then prospectively enrolled.They were divided into a survival group and a mortality group based on their 28 days survival.All patients were tested for serum D-dimer(D-D)and fibrinogen(Fib)levels at admission,and DFR was calculated.The relationship between DFR and the prognosis of patients with acute exacerbation of COPD was tested using a point two column correlation test,and the predictive value of DFR on the survival of patients with acute exacerbation of COPD was analyzed by drawing a receiver operating characteristic(ROC)curve.Results A total of 102 patients with acute exacerbation of COPD were included,of which 18 died,accounting for 17.65％.They were included in the mortality group,while the remaining 84 patients were included in the survival group.The DFR of the mortality group was higher than that of the survival group,and the difference was statistically significant(P＜0.05).Through point two column correlation analysis,there was a positive correlation between DFR and mortality in patients with acute exacerbation of COPD(r=0.431,P＜0.001).ROC curve was drawn,and DFR had certain predictive value for death in patients with acute exacerbation of COPD(AUC=0.795,P＜0.001).Conclusion DFR is highly expressed in dead patients with acute exacerbations of COPD,which can be used as a predictor of survival in patients with acute exacerbations of COPD.
万方数据
维普
