首页|基于既病防变思想的健脾行气解毒法治疗中晚期原发性肝癌患者的效果

基于既病防变思想的健脾行气解毒法治疗中晚期原发性肝癌患者的效果

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目的 研究基于既病防变思想的健脾行气解毒法对中晚期原发性肝癌患者的作用效果.方法 选取安阳市中医院2019年4月至2023年4月收治的80例中晚期原发性肝癌患者,随机分为对照组和观察组,对照组(40例)接受索拉非尼联合放疗,观察组(40例)联合基于既病防变思想的健脾行气解毒法治疗,对比两组中医证候积分、肝功能、肿瘤标志物水平、复发转移情况和不良反应发生率.结果 治疗后,观察组谷草转氨酶(GOT)、谷丙转氨酶(GPT)、总胆红素(TBil)、细胞角蛋白19片段抗原21-1(CYFRA21-1)、甲胎蛋白(AFP)、糖类抗原199(CA199)水平均低于对照组(P<0.05),肿瘤复发转移率及中医证候积分低于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05).结论 基于既病防变思想的健脾行气解毒法治疗中晚期原发性肝癌患者的效果确切,能够降低中医证候积分,改善肝功能,降低肿瘤标志物水平和肿瘤复发转移率,安全性高,具有临床推广价值.
Effect of the Spleen Strengthening,Qi Promotingand Detoxification Method Based on the Concept of Preventing and Treating Existing Diseases on Patients with Advanced Primary Liver Cancer
Objective To study the effects of spleen strengthening,Qi promotingand detoxification method based on the concept of preventing and treating existing diseases on patients with advanced primary liver cancer.Methods Eighty patients with advanced primary liver cancer admitted to Anyang Traditional Chinese Medicine Hospital from April 2019 to April 2023 were randomly divided into control group and observation.The control group(40 cases)accepted sorafenib combined with radiotherapy,and the observation group(40 cases)accepted spleen strengthening,Qi promotingand detoxification method based on the concept of preventing and treating existing diseases.Traditional Chinese medicine syndrome score,liver function,tumor marker level,recurrence and metastasis and incidence of adverse reactions were compared between the two groups.Results After treatment,the levels of glutamic-oxaloacetic transaminase(GOT),glutamic-pyruvic transaminase(GPT),total bilirubin(TBil),cytokeratin 19 fragment antigen 21-1(CYFRA21-1),alpha-fetoprotein(AFP)and carbohydrate antigen 199(CA1 99)in observation group were lower than those in control group(P<0.05).The tumor recurrence and metastasis rate and the traditional Chinese medicine syndrome score of observation group were lower than that of control group(P<0.05).There was no statistical difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Spleen strengthening,Qi promotingand detoxification method based on the concept of preventing and treating existing diseases in the treatment of middle and advanced primary liver cancer patients,which can reduce traditional Chinese medicine syndrome score,improve liver function,reduce tumor marker level and tumor recurrence and metastasis rate,with high safety and clinical promotion value.

prevention of diseasespleen strengthening,Qi promotingand detoxification methodintermediate and advanced primary liver cancerliver function

李江艳、李阳、尹旭

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安阳市中医院肿瘤科,河南安阳 455000

既病防变思想 健脾行气解毒法 中晚期原发性肝癌 肝功能

2024

河南医学研究
河南省医学科学院

河南医学研究

影响因子:0.979
ISSN:1004-437X
年,卷(期):2024.33(8)
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