Evaluation Value of Multi-parameter Magnetic Resonance Imaging for the Efficacy of Neoadjuvant Radiotherapy and Chemotherapy in Locally Advanced Rectal Cancer
Objective To explore the evaluation value of multi-parameter magnetic resonance imaging for the efficacy of neoadjuvant radiotherapy and chemotherapy in locally advanced rectal cancer.Methods Clinical data of 98 patients with locally advanced rectal cancer admitted to Anyang Traditional Chinese Medicine Hospital from June 2021 to June 2023 were retrospectively analyzed,and the patients were divided into CR group(35 cases)and non-CR group(63 cases)according to the efficacy of neoadjuvant chemoradiotherapy.The MRI parameters[apparent diffusion coefficient(ADC),plasma exchange rate,tissue perfusion volume,transposition constant]were compared,and the correlation between MRI multiple parameters and the efficacy of neoadjuvant chemoradiotherapy in locally advanced rectal cancer was analyzed.And the value of MRI multiparametric assessment of the effect of neoadjuvant radiochemotherapy in locally progressive rectal cancer was analyzed by receiver operating characteristic(ROC)curves.Results The ADC before treatment and post-treatment transposition constant in the CR group were lower than those in the nCR group,while post-treatment ADC,pre-treatment plasma exchange rate,pre-treatment transposition constant and pre-treatment tissue perfusion were higher than those in the nCR group(P＜0.05).Binary logistic regression analysis showed that ADC difference,plasma exchange rate difference,transposition constant difference and tissue perfusion volume difference were all related influencing factors of therapeutic efficacy(P＜0.05).The area under the curve(AUC)for evaluating the efficacy of neoadjuvant radiotherapy and chemotherapy in locally advanced rectal cancer using ADC difference,plasma exchange rate difference,transposition constant difference and tissue perfusion difference were 0.941,0.742,0.953,and 0.774,respectively.The sensitivity and specificity were 88.6％/87.3％,88.6％/50.8％,97.1％/82.5％,77.1％/68.3％,respectively.The AUC of the combined evaluation of ADC difference,plasma exchange rate difference,transposition constant difference and tissue perfusion difference for the efficacy of neoadjuvant radiotherapy and chemotherapy in locally advanced rectal cancer was 0.993,with sensitivity and specificity of 91.4％and 100.0％,respectively.Conclusion MRI multi-parameter(ADC,plasma exchange rate,tissue perfusion volume,transposition constant)differential evaluation of neoadjuvant chemotherapy for locally advanced rectal cancer has certain value,and the combined evaluation has higher value.
rectal cancerlocal progressive stagemagnetic resonancemulti-parameter imagingneoadjuvant chemoradiotherapycurative effectappraised value
万方数据
维普
