Exploration of Myocardial Microcirculation Hemodynamics in Patients with Microvascular Angina Pectoris
Objective To explore the changes of myocardial microcirculation hemodynamics and vasoactive substances in patients with primary microvascular angina pectoris.Methods From December 2017 to December 2018,22 inpatients with primary microvascular angina pectoris in Central China Fuwai Hospital were selected as the experimental group,and 18 inpatients without angina pectoris with normal coronary angiography were selected as the control group.The changes of myocardial microcirculation vascular perfusion pressure,resistance and local vasoactive substances were compared between the two groups.Results The systolic pressure,diastolic pressure,mean arterial pressure and pulse pressure index at the coronary artery origin in the experimental group were higher than those in the control group,with statistically significant differences(P＜0.05).The frames required for contrast agent from the origin of the coronary artery to the distal vessels,coronary sinus filling time and microcirculation resistance index in the experimental group were higher than those in the control group,the plasma endothelin-1(ET-1)level was higher than that in the control group,and the level of nitric oxide(NO)was lower than that in the control group,with statistically significant differences(P＜0.05).Conclusion The driving force of blood circulation in patients with primary microvascular angina pectoris is not decreased,the blood flow through myocardial microcirculation is slowed down,and the microcirculation resistance is increased,which is related to the changes of ET-1 and NO levels in local myocardial circulation.
万方数据
维普
