Correlation of Serum TRAF6,activin-A,SFMC Levels with Preeclampsia and the Disease and Pregnancy Outcomes
Objective To analyze the correlation between serum levels of tumor necrosis factor receptor-associated factor 6(TRAF6),glycoprotein hormone-activin-A and soluble fibrin complex(SFMC)and the disease and pregnancy outcomes of preeclampsia patients.Methods A total of 134 cases of preeclampsia patients admitted to the Second Affiliated Hospital of Zhengzhou University from July 2020 to January 2023 were retrospectively selected as the study group,and healthy women during the same period were selected as the control group.According to the degree of preeclampsia,the patients were divided into mild and severe patients.All patients were followed up until 30 days after delivery.The study group was divided into patients with and without adverse pregnancy according to whether adverse pregnancy occurred in this pregnancy outcome.Serum levels of TRAF6,activin-A and SFMC were compared between the two groups,patients with different disease degrees and pregnancy outcomes at admission,and their correlation was analyzed,and the predictive value of detection of serum levels of various indicators at admission for pregnancy outcomes of preeclampsia patients was analyzed.Results The serum levels of TRAF6,activin-A and SFMC in the study group were higher than those in the control group(P＜0.05).Serum levels of TRAF6,activin-A and SFMC in severe patients were higher than those in mild patients(P＜0.05).Serum TRAF6,activin-A and SFMC were positively correlated with the severity of the disease(P＜0.05).The serum levels of TRAF6,activin-A and SFMC in patients with adverse pregnancy were higher than those in patients with good pregnancy(P＜0.05).The area under the curve(AUC)of serum TRAF6,activin-A,and SFMC combined to predict adverse pregnancy in preeclampsia patients at admission was 0.748.Conclusion The expression of serum TRAF6,activin-A and SFMC is closely related to the severity and prognosis of preeclampsia patients.The combined detection of TRAF6,activin-A and SFMC has high application value in predicting adverse pregnancy in preeclampsia patients,and can assist clinical diagnosis and treatment.
万方数据
维普
