Correlation of CCP,IL-6 and SAA with Disease Activity in Patients with Rheumatoid Arthritis
Objective To investigate the correlation between anti cyclic citrullinated peptide(CCP),interleukin-6(IL-6),serum amyloid A(SAA)and disease activity in patients with rheumatoid arthritis(RA).Methods A total of 120 RA patients who were hospitalized in Jiaozuo Coal Industry(Group)Limited Liability Company Central Hospital from January 2019 to January 2021 were selected as the research object.The disease activity of RA patients was evaluated by referring to the disease activity score(DAS28).The patients were divided into remission group(43 cases)(＜2.6 points),mild activity group(32 cases)(2.6-3.2 points),moderate activity group(24 cases)(3.2-5.1 points)and severe activity group(21 cases)(＞5.1 points)according to the DAS28 score.Serum CCP,IL-6 and SAA levels were detected and compared between groups.Pearson correlation analysis was used to analyze the correlation between serum CCP,IL-6,SAA levels and DAS28 scores in RA patients.The diagnostic value of serum CCP,IL-6 and SAA levels for disease activity of RA patients was evaluated by drawing the receiver operator characteristic(ROC)curve.Results The levels of serum CCP,IL-6 and SAA in remission group,mild activity group,moderate activity group and severe activity group increased in turn,and there was significant difference between the groups(P＜0.05).The levels of serum CCP,IL-6 and SAA were positively correlated with the DAS28 score of RA patients(P＜0.05).The area under the curve(AUC)of serum CCP,IL-6 and SAA for single and combined diagnosis of disease activity in RA patients were 0.681,0.663,0.704 and 0.845,respectively.The AUC of combined diagnosis was greater than that of single diagnosis.Conclusion The levels of serum CCP,IL-6 and SAA are positively correlated with the disease activity of RA patients,and the combined diagnosis of RA disease activity has the highest efficacy.
万方数据
维普
